Bariatric surgery was born in the 1950s at the University of Minnesota. From this time, it continues to evolve and, by the same\ntoken, gives new or better possibilities to treat not only obesity but also associated comorbidities. Metabolomics is also a\nrelatively young science discipline, and similarly, it shows great potential for the comprehensive study of the dynamic alterations\nof the metabolome. It has been widely used in medicine, biology studies, biomarker discovery, and prognostic evaluations.\nCurrently, several dozen metabolomics studies were performed to study the effects of bariatric surgery. LC-MS and NMR are the\nmost frequently used techniques to study main effects of RYGB or SG. Research has yield many interesting results involving not\nonly clinical parameters but also molecular modulations. Detected changes pertain to amino acid, lipids, carbohydrates, or gut\nmicrobiota alterations. It proves that including bariatric surgery to metabolic surgery is warranted. However, many molecular\nmodulations after those procedures remain unexplained. Therefore, application of metabolomics to study this field seems to be a\nproper solution. New findings can suggest new directions of surgery technics modifications, contribute to broadening knowledge\nabout obesity and diseases related to it, and perhaps develop nonsurgical methods of treatment in the future.
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